9CYP

Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K)

9CYP の概要

• エントリーDOI: 10.2210/pdb9cyp/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: ptp1b, phosphatase, allostery, ptp, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37454.05

構造登録者

Ebrahim, A.,Perdikari, A.,Woods, V.A.,Lawler, K.,Bounds, R.,Singh, N.I.,Mehlman, T.,Riley, B.T.,Sharma, S.,Morris, J.W.,Keogh, J.M.,Henning, E.,Smith, M.,Farooqi, I.S.,Keedy, D.A. (登録日: 2024-08-02, 公開日: 2024-08-21)

• 主引用文献: Perdikari, A.,Woods, V.,Ebrahim, A.,Lawler, K.,Bounds, R.,Singh, N.,Mehlman, T.,Riley, B.,Sharma, S.,Morris, J.,Keogh, J.,Henning, E.,Smith, M.,Farooqi, I.,Keedy, D.; Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy; Biorxiv, 2024; DOI: 10.1101/2024.08.05.603709

実験手法

X-RAY DIFFRACTION (1.99 Å)