9CUO

Crystal structure of CRBN with compound 3

This is a non-PDB format compatible entry.

Summary for 9CUO

• Entry DOI: 10.2210/pdb9cuo/pdb
• Descriptor: Protein cereblon, ZINC ION, (3S)-3-(3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidine-2,6-dione, ... (6 entities in total)
• Functional Keywords: crbn, e3, protein degradation, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 79190.35

Authors

Zheng, X.,Ji, N.,Campbell, V.,Slavin, A.,Zhu, X.,Chen, D.,Rong, H.,Enerson, B.,Mayo, M.,Sharma, K.,Browne, C.M.,Klaus, C.R.,Li, H.,Massa, G.,McDonald, A.A.,Shi, Y.,Sintchak, M.,Skouras, S.,Walther, D.M.,Yuan, K.,Zhang, Y.,Kelleher, J.,Guang, L.,Luo, X.,Mainolfi, N.,Weiss, M.M. (deposition date: 2024-07-26, release date: 2024-08-28)

• Primary citation: Zheng, X.,Ji, N.,Campbell, V.,Slavin, A.,Zhu, X.,Chen, D.,Rong, H.,Enerson, B.,Mayo, M.,Sharma, K.,Browne, C.M.,Klaus, C.R.,Li, H.,Massa, G.,McDonald, A.A.,Shi, Y.,Sintchak, M.,Skouras, S.,Walther, D.M.,Yuan, K.,Zhang, Y.,Kelleher, J.,Liu, G.,Luo, X.,Mainolfi, N.,Weiss, M.M.; Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.; J.Med.Chem., 2024; PubMed: 39151120; DOI: 10.1021/acs.jmedchem.4c01305

Experimental method

X-RAY DIFFRACTION (1.6 Å)