9CTX

X-ray crystal structure of multi-drug resistant HIV-1 protease (P51) in complex with Darunavir

Summary for 9CTX

• Entry DOI: 10.2210/pdb9ctx/pdb
• Related: 6MKL
• Descriptor: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hiv-1 protease, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 11515.48

Authors

Hayashi, H.,Yedidi, R.,Bulut, H.,Das, D.,Mitsuya, H. (deposition date: 2024-07-25, release date: 2024-08-07)

• Primary citation: Das, D.,Hayashi, H.,Yedidi, R.S.,Bulut, H.,Mitsuya, H.; Secondary amino-acid substitutions contribute to the emergence of HIV protease inhibitor resistance as directly as primary amino-acid substitutions.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)