9CT8

Tricomplex of Compound 2, KRAS G12D, and CypA

This is a non-PDB format compatible entry.

Summary for 9CT8

• Entry DOI: 10.2210/pdb9ct8/pdb
• Descriptor: Isoform 2B of GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (7 entities in total)
• Functional Keywords: kras, cypa, g12d, gtpase, tri-complex, inhibitor-complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 78087.09

Authors

Zhang, D.,Bar Ziv, T.,Knox, J.E.,Yano, J.K. (deposition date: 2024-07-24, release date: 2025-07-23)

• Primary citation: Wildes, D.; A neomorphic protein interface catalyzes covalent inhibition of RAS; Science, 2025; DOI: 10.1126/science.ads0239

Experimental method

X-RAY DIFFRACTION (1.28 Å)