9CKY

X-ray diffraction structure of papain co-crystallized with novel biosynthetic inhibitor amine-65

This is a non-PDB format compatible entry.

Summary for 9CKY

• Entry DOI: 10.2210/pdb9cky/pdb
• Related: 9CKT 9CKW
• Descriptor: Papain, METHANOL, (3S)-4-({(1S)-2-[(8-aminooctyl)amino]-1-cyclobutyl-2-oxoethyl}amino)-3-hydroxy-4-oxobutanoic acid, ... (4 entities in total)
• Functional Keywords: protease, complex, inhibitor-bound, hydrolase
• Biological source: Carica papaya (papaya)
• Total number of polymer chains: 1
• Total formula weight: 23855.82

Authors

Vlahakis, N.W.,Liu, M.,Tang, Y.,Rodriguez, J.A. (deposition date: 2024-07-10, release date: 2025-06-04)

• Primary citation: Liu, M.,Zang, X.,Vlahakis, N.W.,Rodriguez, J.A.,Ohashi, M.,Tang, Y.; Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors; Nat.Chem.Biol., 2025; DOI: 10.1038/s41589-025-01907-2

Experimental method

X-RAY DIFFRACTION (1.4 Å)