9CJL

Molecular basis of TMED9 dodecamer

9CJL の概要

• エントリーDOI: 10.2210/pdb9cjl/pdb
• EMDBエントリー: 45635
• 分子名称: Transmembrane emp24 domain-containing protein 9, [(2R)-2-[(E)-octadec-9-enoyl]oxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] (E)-octadec-9-enoate (2 entities in total)
• 機能のキーワード: tmed9, misfolded protein, secretory pathway, cryo-em, protein transport
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 329818.87

構造登録者

Le, X.,Xiong, P. (登録日: 2024-07-06, 公開日: 2024-10-02)

• 主引用文献: Xiao, L.,Pi, X.,Goss, A.C.,El-Baba, T.,Ehrmann, J.F.,Grinkevich, E.,Bazua-Valenti, S.,Padovano, V.,Alper, S.L.,Carey, D.,Udeshi, N.D.,Carr, S.A.,Pablo, J.L.,Robinson, C.V.,Greka, A.,Wu, H.; Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway.; Sci Adv, 10:eadp2221-eadp2221, 2024; PubMed: 39303030; DOI: 10.1126/sciadv.adp2221

実験手法

ELECTRON MICROSCOPY (5.5 Å)