9CIH
Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide across O4-methyl threofuranosyl thymidine in DNA template at extension stage
This is a non-PDB format compatible entry.
Summary for 9CIH
Entry DOI | 10.2210/pdb9cih/pdb |
Descriptor | DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(A1A0L)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ... (7 entities in total) |
Functional Keywords | dna binding protein, dna polymerase, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 55497.79 |
Authors | Tomar, R.,Stone, M.P.,Egli, M. (deposition date: 2024-07-03, release date: 2024-09-18, Last modification date: 2024-10-16) |
Primary citation | Tomar, R.,Ghodke, P.P.,Patra, A.,Smyth, E.,Pontarelli, A.,Copp, W.,Guengerich, F.P.,Chaput, J.C.,Wilds, C.J.,Stone, M.P.,Egli, M. DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta. Biochemistry, 63:2425-2439, 2024 Cited by PubMed: 39259676DOI: 10.1021/acs.biochem.4c00387 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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