9CBT

Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10

Summary for 9CBT

• Entry DOI: 10.2210/pdb9cbt/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, 2-{[(2S)-6-[(Z)-(1-{[(2R,3R,4R,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-4-hydroxy-2-sulfanyloxolan-3-yl]oxy}tetradecylidene)amino]-2-{[(benzyloxy)carbonyl]amino}hexanoyl]amino}-N,N,N-triethylethan-1-aminium (non-preferred name), ... (6 entities in total)
• Functional Keywords: deacetylase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65355.80

Authors

Fenwick, M.K.,Young, H.J.,Lin, H. (deposition date: 2024-06-20, release date: 2024-08-07)

• Primary citation: Fenwick, M.K.,Young, J.H.,Lin, H.; Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)