9CBT
Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10
Summary for 9CBT
Entry DOI | 10.2210/pdb9cbt/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, 2-{[(2S)-6-[(Z)-(1-{[(2R,3R,4R,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-4-hydroxy-2-sulfanyloxolan-3-yl]oxy}tetradecylidene)amino]-2-{[(benzyloxy)carbonyl]amino}hexanoyl]amino}-N,N,N-triethylethan-1-aminium (non-preferred name), ... (6 entities in total) |
Functional Keywords | deacetylase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65355.80 |
Authors | |
Primary citation | Fenwick, M.K.,Young, J.H.,Lin, H. Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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