9CBT

Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10

9CBT の概要

• エントリーDOI: 10.2210/pdb9cbt/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, 2-{[(2S)-6-[(Z)-(1-{[(2R,3R,4R,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-4-hydroxy-2-sulfanyloxolan-3-yl]oxy}tetradecylidene)amino]-2-{[(benzyloxy)carbonyl]amino}hexanoyl]amino}-N,N,N-triethylethan-1-aminium (non-preferred name), ... (6 entities in total)
• 機能のキーワード: deacetylase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65355.80

構造登録者

Fenwick, M.K.,Young, H.J.,Lin, H. (登録日: 2024-06-20, 公開日: 2024-08-07)

• 主引用文献: Fenwick, M.K.,Young, J.H.,Lin, H.; Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10; To Be Published,

実験手法

X-RAY DIFFRACTION (1.95 Å)