9C6X

Crystal Structure of a single chain trimer composed of HLA-B*39:01 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2

Summary for 9C6X

Entry DOI	10.2210/pdb9c6x/pdb
Related	4O2E 9C6V 9C6W
Descriptor	NACHT, LRR and PYD domains-containing protein 2,Beta-2-microglobulin,MHC class I antigen, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	hla class i histocompatibility antigen, b-39 alpha chain, beta-2-microglobulin, nlrp2, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	46990.76
Authors	Sharma, R.,Amdare, N.P.,Celikgil, A.,Garforth, S.J.,DiLorenzo, T.P.,Almo, S.C.,Ghosh, A. (deposition date: 2024-06-09, release date: 2024-09-04)
Primary citation	Sharma, R.,Amdare, N.P.,Ghosh, A.,Schloss, J.,Sidney, J.,Garforth, S.J.,Lopez, Y.,Celikgil, A.,Sette, A.,Almo, S.C.,DiLorenzo, T.P. Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes. J.Biol.Chem., :107702-107702, 2024 Cited by PubMed: 39173948 DOI: 10.1016/j.jbc.2024.107702 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation