9BY4

Co-crystal structure of the kinase domain of EGFR with non-covalent osimertinib

Summary for 9BY4

• Entry DOI: 10.2210/pdb9by4/pdb
• Descriptor: Epidermal growth factor receptor, 1,3-PROPANDIOL, ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide, ... (5 entities in total)
• Functional Keywords: egfr, kinase domain, oncoprotein, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39406.64

Authors

Ashtekar, K.D.,Stayrook, S.E.,Lemmon, M.A. (deposition date: 2024-05-23, release date: 2025-05-28, Last modification date: 2025-10-01)

• Primary citation: Tsutsui, Y.,Ashtekar, K.D.,Stayrook, S.,Lemmon, M.A.; Comprehensive characterization of EGFR-tyrosine kinase inhibitor interactions probed by hydrogen-deuterium exchange and mass spectrometry (HDX-MS); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.307 Å)