9BRX

SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 10

This is a non-PDB format compatible entry.

Summary for 9BRX

• Entry DOI: 10.2210/pdb9brx/pdb
• Related: 9BRV 9BRW
• Descriptor: Papain-like protease nsp3, (4R)-N-(2,4-dimethylphenyl)-7-methyl[1,2,4]triazolo[4,3-a]pyrimidin-5-amine, ZINC ION, ... (5 entities in total)
• Functional Keywords: plpro, sars-cov-2, drug discovery, inhibitor, viral protein, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 36471.78

Authors

Amporndanai, K.,Zhao, B.,Fesik, S.W. (deposition date: 2024-05-11, release date: 2024-07-31)

• Primary citation: Taylor, A.J.,Amporndanai, K.,Rietz, T.A.,Zhao, B.,Thiruvaipati, A.,Wei, Q.,South, T.M.,Crow, M.M.,Apakama, C.,Sensintaffar, J.L.,Phan, J.,Lee, T.,Fesik, S.W.; Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PLpro); Acs Med.Chem.Lett., 2024; DOI: 10.1021/acsmedchemlett.4c00238

Experimental method

X-RAY DIFFRACTION (1.8 Å)