9BRV
SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 5
This is a non-PDB format compatible entry.
Summary for 9BRV
Entry DOI | 10.2210/pdb9brv/pdb |
Descriptor | Papain-like protease nsp3, N-[2-(dimethylamino)ethyl]-N'-(3-methylphenyl)thiourea, ZINC ION, ... (6 entities in total) |
Functional Keywords | plpro, sars-cov-2, drug discovery, inhibitor, viral protein, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
Total number of polymer chains | 2 |
Total formula weight | 73482.88 |
Authors | Amporndanai, K.,Zhao, B.,Fesik, S.W. (deposition date: 2024-05-11, release date: 2024-07-31, Last modification date: 2024-09-04) |
Primary citation | Taylor, A.J.,Amporndanai, K.,Rietz, T.A.,Zhao, B.,Thiruvaipati, A.,Wei, Q.,South, T.M.,Crow, M.M.,Apakama, C.,Sensintaffar, J.L.,Phan, J.,Lee, T.,Fesik, S.W. Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL pro ). Acs Med.Chem.Lett., 15:1351-1357, 2024 Cited by PubMed: 39140055DOI: 10.1021/acsmedchemlett.4c00238 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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