9BR7

Crystal structure of human succinyl-CoA:glutarate-CoA transferase (SUGCT) in complex with Losartan carboxylic acid

This is a non-PDB format compatible entry.

Summary for 9BR7

• Entry DOI: 10.2210/pdb9br7/pdb
• Descriptor: Succinate--hydroxymethylglutarate CoA-transferase, losartan carboxylic acid, AMMONIUM ION, ... (5 entities in total)
• Functional Keywords: sugct, succinyl-coa, glutarate, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 181069.97

Authors

Wu, R.,Lazarus, M.B. (deposition date: 2024-05-10, release date: 2024-08-07)

• Primary citation: Wu, R.,Khamrui, S.,Dodatko, T.,Leandro, J.,Sabovic, A.,Violante, S.,Cross, J.R.,Marsan, E.,Kumar, K.,DeVita, R.J.,Lazarus, M.B.,Houten, S.M.; Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1.; Acs Chem.Biol., 19:1544-1553, 2024; PubMed: 38915184; DOI: 10.1021/acschembio.4c00204

Experimental method

X-RAY DIFFRACTION (2.08 Å)