9BPE

Joint X-ray/neutron structure of Thermus thermophilus serine hydroxymethyltransferase (TthSHMT) in internal aldimine state and folinic acid bound

Summary for 9BPE

• Entry DOI: 10.2210/pdb9bpe/pdb
• Descriptor: Serine hydroxymethyltransferase, SULFATE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (5 entities in total)
• Functional Keywords: pyridoxal 5'-phosphate, plp, fold type 1, one carbon metabolism, transferase
• Biological source: Thermus thermophilus HB8
• Total number of polymer chains: 2
• Total formula weight: 89381.91

Authors

Drago, V.N.,Kovalevsky, A. (deposition date: 2024-05-07, release date: 2024-08-28)

• Primary citation: Drago, V.N.,Phillips, R.S.,Kovalevsky, A.; Universality of critical active site glutamate as an acid-base catalyst in serine hydroxymethyltransferase function.; Chem Sci, 15:12827-12844, 2024; PubMed: 39148791; DOI: 10.1039/d4sc03187c

Experimental method

NEUTRON DIFFRACTION (2.3 Å)
X-RAY DIFFRACTION (2 Å)