9BP9
Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, dimer form
Summary for 9BP9
Entry DOI | 10.2210/pdb9bp9/pdb |
EMDB information | 44765 |
Descriptor | DNA polymerase theta, (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide (2 entities in total) |
Functional Keywords | dna repair, helicase, atpase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 200510.90 |
Authors | |
Primary citation | Ito, F.,Li, Z.,Minakhin, L.,Chandramouly, G.,Tyagi, M.,Betsch, R.,Krais, J.J.,Taberi, B.,Vekariya, U.,Calbert, M.,Skorski, T.,Johnson, N.,Chen, X.S.,Pomerantz, R.T. Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun, 15:7003-7003, 2024 Cited by PubMed: 39143110DOI: 10.1038/s41467-024-51351-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.21 Å) |
Structure validation
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