9BOT

Human mesotrypsin (PRSS3) unliganded and in autoinhibited (E*) conformation

Summary for 9BOT

• Entry DOI: 10.2210/pdb9bot/pdb
• Related: 9BOS
• Descriptor: Trypsin-3, SULFATE ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: serine protease, autoinhibited, conformational variability, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 24670.82

Authors

Coban, M.,Sankaran, B.,Radisky, E.S. (deposition date: 2024-05-06, release date: 2025-06-11)

• Primary citation: Coban, M.,Gokara, M.,Vargas, L.M.F.,Tanzer, S.,Zhou, S.,Hockla, A.,Sankaran, B.,Caulfield, T.R.,Radisky, E.S.; Discovery of an autoinhibited conformation in mesotrypsin reveals a new strategy for selective serine protease inhibition.; Sci Adv, 2025; DOI: 10.1126/sciadv.adu9129

Experimental method

X-RAY DIFFRACTION (1.6 Å)