9BLH

Crystal structure of calcium/calmodulin-dependent protein kinase type II subunit delta complexed with ribociclib

Summary for 9BLH

• Entry DOI: 10.2210/pdb9blh/pdb
• Descriptor: Calcium/calmodulin-dependent protein kinase type II subunit delta, 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (3 entities in total)
• Functional Keywords: kinase, protein kinase, phosphorylation, calcium/calmodulin, cytosolic, transferase-transferase inhibitor complex, ribociclib, transferase, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 69233.78

Authors

Tomchick, D.R.,Majumdar, A.,Tagliabracci, V. (deposition date: 2024-04-30, release date: 2025-05-07)

• Primary citation: Ye, J.S.,Majumdar, A.,Park, B.C.,Black, M.H.,Hsieh, T.-S.,Osinski, A.,Servage, K.A.,Kulkarni, K.,Naidoo, J.,Alto, N.M.,Stratton, M.M.,Ready, J.M.,Pawlowski, K.,Tomchick, D.R.,Tagliabracci, V.; Bacterial ubiquitin ligase engineered for small molecule and protein target identification; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.35 Å)