9BK2
Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (S-enantiomer, monoclinic P form)
これはPDB形式変換不可エントリーです。
9BK2 の概要
| エントリーDOI | 10.2210/pdb9bk2/pdb |
| 分子名称 | L-lactate dehydrogenase A chain, DIMETHYL SULFOXIDE, (2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, ... (5 entities in total) |
| 機能のキーワード | lactate dehydrogenase, oxidoreductase, ldha, inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| 由来する生物種 | Homo sapiens (human) |
| タンパク質・核酸の鎖数 | 4 |
| 化学式量合計 | 158255.10 |
| 構造登録者 | Lovell, S.,Cooper, A.,Battaile, K.P.,Sharma, H.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2024-04-26, 公開日: 2024-07-10) |
| 主引用文献 | Sharma, H.,Mondal, S.,Urquiza, U.,Esparza, C.,Bartlett, S.,Santa-Pinter, L.,Hill, H.,White, M.,Sharma, P.,Luckett-Chastain, L.,Cooper, A.,Rasel, M.,Gao, P.,Battaile, K.P.,Shukla, S.K.,Lovell, S.,Ihnat, M.A. Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur.J.Med.Chem., 275:116598-116598, 2024 Cited by PubMed: 38925013DOI: 10.1016/j.ejmech.2024.116598 主引用文献が同じPDBエントリー |
| 実験手法 | X-RAY DIFFRACTION (1.85 Å) |
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