Summary for 9BJ1
Entry DOI | 10.2210/pdb9bj1/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 1,2-ETHANEDIOL, ... (9 entities in total) |
Functional Keywords | hpk1, map4k1, cancer, pharmacology, kinase, inhibitor, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 72176.37 |
Authors | Kiefer, J.R.,Tellis, J.C.,Chan, B.K.,Wang, W.,Wu, P.,Choo, E.F.,Heffron, T.P.,Wei, B.,Siu, M. (deposition date: 2024-04-24, release date: 2024-10-02) |
Primary citation | Tellis, J.C.,Wei, B.,Siu, M.,An, L.,Chan, G.K.,Chen, Y.,Du, X.,Gazzard, L.,Hu, B.,Kiefer, J.,Kakiuchi-Kiyota, S.,Lainchbury, M.,Linehan, J.L.,Luo, X.,Malhotra, S.,Mendonca, R.,Pang, J.,Ran, Y.,Sethuraman, V.,Seward, E.,Sneeringer, C.,Su, D.,Wang, W.,Wu, P.,Moffat, J.G.,Heffron, T.P.,Choo, E.F.,Chan, B.K. Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1. Acs Med.Chem.Lett., 15:1606-1614, 2024 Cited by PubMed: 39291002DOI: 10.1021/acsmedchemlett.4c00319 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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