9BCG の概要
エントリーDOI | 10.2210/pdb9bcg/pdb |
関連するBIRD辞書のPRD_ID | PRD_900001 |
分子名称 | Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 7-[(4R,5S,6P)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-4,5-dimethoxy-1-methyl-1H-indole-2-carboxylic acid, ... (4 entities in total) |
機能のキーワード | mcl-1, drug discovery, apoptosis |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 58283.74 |
構造登録者 | |
主引用文献 | Tarr, J.C.,Salovich, J.M.,Aichinger, M.,Jeon, K.,Veerasamy, N.,Sensintaffar, J.L.,Arnhof, H.,Samwer, M.,Christov, P.P.,Kim, K.,Wunberg, T.,Schweifer, N.,Trapani, F.,Arnold, A.,Martin, F.,Zhao, B.,Miriyala, N.,Sgubin, D.,Fogarty, S.,Moore, W.J.,Stott, G.M.,Olejniczak, E.T.,Engelhardt, H.,Rudolph, D.,Lee, T.,McConnell, D.B.,Fesik, S.W. Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. J.Med.Chem., 67:14370-14393, 2024 Cited by PubMed: 39102508DOI: 10.1021/acs.jmedchem.4c01188 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.898 Å) |
構造検証レポート
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