9BC7
HCN1 M305L holo
Summary for 9BC7
Entry DOI | 10.2210/pdb9bc7/pdb |
EMDB information | 42116 42117 44425 44426 |
Descriptor | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (3 entities in total) |
Functional Keywords | membrane protein, nanodisc, transport protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 309265.06 |
Authors | Kim, E.D.,Nimigean, C.M. (deposition date: 2024-04-08, release date: 2024-07-31, Last modification date: 2024-08-21) |
Primary citation | Kim, E.D.,Wu, X.,Lee, S.,Tibbs, G.R.,Cunningham, K.P.,Di Zanni, E.,Perez, M.E.,Goldstein, P.A.,Accardi, A.,Larsson, H.P.,Nimigean, C.M. Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632:451-459, 2024 Cited by PubMed: 39085604DOI: 10.1038/s41586-024-07743-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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