9B9Y

Structural mechanism of CB1R binding to peripheral and biased inverse agonists

Summary for 9B9Y

• Entry DOI: 10.2210/pdb9b9y/pdb
• EMDB information: 44392
• Descriptor: Cannabinoid receptor 1,Glycogen synthase, CNb36, N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (3 entities in total)
• Functional Keywords: obesity, membrane protein, nanobody, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 75305.57

Authors

Kumari, P.,Szabolcs, D.,Enos, M.D.,Ramesh, K.,Lim, D.,Hassan, S.A.,Kunos, G.,Iyer, M.R.,Rosenbaum, D.M. (deposition date: 2024-04-03, release date: 2024-11-20)

• Primary citation: Kumari, P.,Szabolcs, D.,Enos, M.D.,Ramesh, K.,Lim, D.,Hassan, S.A.,Kunos, G.,Iyer, M.R.,Rosenbaum, D.M.; Structural mechanism of CB1R binding to peripheral and biased inverse agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.5 Å)