9B8C の概要
| エントリーDOI | 10.2210/pdb9b8c/pdb |
| EMDBエントリー | 44342 |
| 分子名称 | Envelope glycoprotein gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein gp41, ... (10 entities in total) |
| 機能のキーワード | hiv env, immune complex, macaque antibody, viral protein, v1v2 apex, viral protein-immune system complex, viral protein/immune system |
| 由来する生物種 | Human immunodeficiency virus 1 詳細 |
| タンパク質・核酸の鎖数 | 14 |
| 化学式量合計 | 342996.14 |
| 構造登録者 | |
| 主引用文献 | Ma, K.M.,Sutton, H.J.,Pratap, P.P.,Steichen, J.M.,Carnathan, D.,Quinn, J.,Kalyuzhniy, O.,Liguori, A.,Agrawal, S.,Baboo, S.,Madden, P.,Cottrell, C.A.,Willis, J.R.,Lee, J.H.,Landais, E.,Hu, X.,Ramezani-Rad, P.,Ozorowski, G.,Lewis, V.R.,Diedrich, J.K.,Zhou, X.,Altheide, T.K.,Phelps, N.,Georgeson, E.,Alavi, N.B.,Lu, D.,Eskandarzadeh, S.,Kubitz, M.,Adachi, Y.,Mullen, T.M.,Silva, M.,Melo, M.B.,Himansu, S.,Irvine, D.J.,Burton, D.R.,Yates 3rd, J.R.,Paulson, J.C.,Sok, D.,Wilson, I.A.,Silvestri, G.,Ward, A.B.,Crotty, S.,Schief, W.R. HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates. Sci Immunol, 10:eadt6660-eadt6660, 2025 Cited by PubMed Abstract: An effective prophylactic HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). bnAbs to the Apex region of the HIV envelope glycoprotein (Env) are promising targets for vaccination because of their relatively low somatic hypermutation compared with other bnAbs. Most Apex bnAbs engage Env using an exceptionally long heavy-chain complementarity-determining region 3 (HCDR3) containing specific binding motifs, which reduces bnAb precursor frequency and makes priming of rare bnAb precursors a likely limiting step in the path to Apex bnAb induction. We found that adjuvanted protein or mRNA lipid nanoparticle (LNP) immunization of rhesus macaques with ApexGT6, an Env trimer engineered to bind Apex bnAb precursors, consistently induced Apex bnAb-related precursors with long HCDR3s bearing bnAb-like sequence motifs. Cryo-electron microscopy revealed that elicited Apex bnAb-related HCDR3s had structures combining elements of several prototype Apex bnAbs. These results achieve a critical HIV vaccine development milestone in outbred primates. PubMed: 40845127DOI: 10.1126/sciimmunol.adt6660 主引用文献が同じPDBエントリー |
| 実験手法 | ELECTRON MICROSCOPY (3.3 Å) |
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