9B1Q
Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN1 inhibitor
This is a non-PDB format compatible entry.
Summary for 9B1Q
Entry DOI | 10.2210/pdb9b1q/pdb |
Related | 8VTQ 8VUG 8W1H 8W2K 9AT2 9B17 |
Descriptor | Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, (5P)-1-[(imidazolidin-1-yl)methyl]-5-(1H-indol-3-yl)-1H-1,2,3-benzotriazole, ... (5 entities in total) |
Functional Keywords | inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 185342.60 |
Authors | Geeraerts, Z.,Yeh, S.-R. (deposition date: 2024-03-13, release date: 2024-08-21, Last modification date: 2024-09-11) |
Primary citation | Geeraerts, Z.,Ishigami, I.,Lewis-Ballester, A.,Pham, K.N.,Kozlova, A.,Mathieu, C.,Frederick, R.,Yeh, S.R. Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase. J.Med.Chem., 67:14543-14552, 2024 Cited by PubMed: 39106326DOI: 10.1021/acs.jmedchem.4c01360 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.624 Å) |
Structure validation
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