9B00
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution
This is a non-PDB format compatible entry.
Summary for 9B00
Entry DOI | 10.2210/pdb9b00/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total) |
Functional Keywords | chloramphenicol; berberine; antibiotic; 70s ribosome; x-ray structure; translation inhibitor; binding affinity; peptidyl transferase center; nascent peptide exit tunnel, ribosome |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4569739.59 |
Authors | Batool, Z.,Pavlova, J.A.,Paranjpe, M.N.,Tereshchenkov, A.G.,Lukianov, D.A.,Osterman, I.A.,Bogdanov, A.A.,Sumbatyan, N.V.,Polikanov, Y.S. (deposition date: 2024-03-11, release date: 2024-08-07, Last modification date: 2024-09-25) |
Primary citation | Batool, Z.,Pavlova, J.A.,Paranjpe, M.N.,Tereshchenkov, A.G.,Lukianov, D.A.,Osterman, I.A.,Bogdanov, A.A.,Sumbatyan, N.V.,Polikanov, Y.S. Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity. Structure, 32:1429-, 2024 Cited by PubMed: 39019034DOI: 10.1016/j.str.2024.06.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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