9B00

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution

これはPDB形式変換不可エントリーです。

9B00 の概要

• エントリーDOI: 10.2210/pdb9b00/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• 機能のキーワード: chloramphenicol; berberine; antibiotic; 70s ribosome; x-ray structure; translation inhibitor; binding affinity; peptidyl transferase center; nascent peptide exit tunnel, ribosome
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4569739.59

構造登録者

Batool, Z.,Pavlova, J.A.,Paranjpe, M.N.,Tereshchenkov, A.G.,Lukianov, D.A.,Osterman, I.A.,Bogdanov, A.A.,Sumbatyan, N.V.,Polikanov, Y.S. (登録日: 2024-03-11, 公開日: 2024-08-07)

• 主引用文献: Batool, Z.,Pavlova, J.A.,Paranjpe, M.N.,Tereshchenkov, A.G.,Lukianov, D.A.,Osterman, I.A.,Bogdanov, A.A.,Sumbatyan, N.V.,Polikanov, Y.S.; Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity.; Structure, 2024; PubMed: 39019034; DOI: 10.1016/j.str.2024.06.013

実験手法

X-RAY DIFFRACTION (2.8 Å)