9AU3

Crystal structure of GenB2 in complex with G418

Summary for 9AU3

• Entry DOI: 10.2210/pdb9au3/pdb
• Descriptor: 6'-epimerase, C-6' aminotransferase, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GENETICIN, ... (5 entities in total)
• Functional Keywords: gentamicin biosynthesis, g418, pyridoxamine-5'-phosphate (pmp), antibiotic
• Biological source: Micromonospora echinospora
• Total number of polymer chains: 1
• Total formula weight: 45445.84

Authors

De Oliveira, G.S.,Bury, P.S.,Huang, F.,Li, Y.,Araujo, N.C.,Zhou, J.,Sun, Y.,Leeper, F.,Leadlay, P.,Dias, M.V.B. (deposition date: 2024-02-28, release date: 2024-09-11)

• Primary citation: Oliveira, G.S.,Dos S Bury, P.,Huang, F.,Li, Y.,Araujo, N.C.,Zhou, J.,Sun, Y.,Leeper, F.J.,Leadlay, P.F.,Dias, M.V.B.; Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis.; Acs Chem.Biol., 2024; PubMed: 39207862; DOI: 10.1021/acschembio.4c00334

Experimental method

X-RAY DIFFRACTION (1.35 Å)