9ZL9

Crystal structure of DCAF1 in complex with SDIPTAC C7

This is a non-PDB format compatible entry.

Summary for 9ZL9

• Entry DOI: 10.2210/pdb9zl9/pdb
• Descriptor: DDB1- and CUL4-associated factor 1, (4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide, (4P,4'P)-5,5'-[(1E,30E)-3,29-dioxo-7,10,13,16,19,22,25-heptaoxa-4,28-diazahentriaconta-1,30-diene-1,31-diyl]bis{N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide}, ... (4 entities in total)
• Functional Keywords: sdiptac, protac, hiv, e3 ligase, inhibitor, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 216317.43

Authors

Mabanglo, M.F.,Srivastava, S.,Hoffer, L.,Ramnauth, J.,Vedadi, M. (deposition date: 2025-12-08, release date: 2026-05-20)

• Primary citation: Mabanglo, M.F.,Vedadi, M.; Self-dimerization Induced Proximity Targeting Chimeras (SDIPTAC) lead to DCAF1 loss of function and inhibition of HIV replication; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)