9ZKD

Structure of RY12 domain of rabbit RyR1 complexed with ADP and Mg2+ (mimicking muscle fatigue)

Summary for 9ZKD

• Entry DOI: 10.2210/pdb9zkd/pdb
• EMDB information: 74364
• Descriptor: Ryanodine receptor 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: sarcoplasmic reticulum, intracellular calcium channel, excitation-contraction coupling, complex, membrane protein
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 24685.86

Authors

Kim, K.,Clarke, O.B. (deposition date: 2025-12-05, release date: 2026-09-16)

• Primary citation: Kim, K.,Li, H.,Yuan, Q.,Melville, Z.,Zalk, R.,des Georges, A.,Frank, J.,Hendrickson, W.A.,Marks, A.R.,Clarke, O.B.; Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene; Nat Commun, 2026; DOI: 10.1038/s41467-026-76519-y

Experimental method

ELECTRON MICROSCOPY (2.32 Å)