9XU9

Crystal structure of EGFR T790M/C797S/L858R mutant in complex with (2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

This is a non-PDB format compatible entry.

Summary for 9XU9

• Entry DOI: 10.2210/pdb9xu9/pdb
• Descriptor: Epidermal growth factor receptor, 5-chloranyl-~{N}4-(2-dimethylphosphorylphenyl)-~{N}2-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitro-phenyl]pyrimidine-2,4-diamine (2 entities in total)
• Functional Keywords: egfr, kinase, cell signaling transport, lung cancer, inhibitor., signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38236.47

Authors

Wang, Y.Y.,Ma, L.L. (deposition date: 2025-11-24, release date: 2025-12-24)

• Primary citation: Wang, Y.Y.,Ma, L.L.; Crystal structure of EGFR T790M/C797S/L858R mutant in complex with (2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.84 Å)