9WGK

Crystal structure of OcuKAI2d2 from Orobanche cumana bound to Dehydrocostus Lactone

This is a non-PDB format compatible entry.

Summary for 9WGK

• Entry DOI: 10.2210/pdb9wgk/pdb
• Descriptor: OcuKAI2d2 protein, (3~{a}~{R},6~{a}~{S},9~{a}~{R},9~{b}~{S})-3,6,9-trimethylidene-3~{a},4,5,6~{a},7,8,9~{a},9~{b}-octahydroazuleno[4,5-b]furan-2-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kai2d receptors, orobanche cumana, dehydrocostus lactone, hydrolase
• Biological source: Orobanche cernua var. cumana
• Total number of polymer chains: 1
• Total formula weight: 30741.06

Authors

Hameed, U.F.S.,Arold, S.T. (deposition date: 2025-08-24, release date: 2026-05-20)

Primary citation

Shahul Hameed, U.F.,Jamil, M.,Zarban, R.,Saito, Y.,Alashoor, K.,Balakrishna, A.,Asami, T.,Arold, S.T.,Al-Babili, S.
Orobanche cumana KAI2d2 mediates perception of dehydrocostus lactone and strigolactones and is inhibited by triazole ureas.
Plant Commun., :101889-101889, 2026

PubMed Abstract: Seed germination of the parasitic plant Orobanche cumana is induced by host-derived strigolactones and dehydrocostus lactone. We show that the KAI2d2 receptor perceives both ligands through distinct modes of interaction. Triazole urea compounds covalently inhibit KAI2d receptors, suppressing germination without affecting sunflower growth.

PubMed: 42104616
DOI: 10.1016/j.xplc.2026.101889

Experimental method

X-RAY DIFFRACTION (2.45 Å)