9UNY

Natural product inhibitor of glyceraldehyde-3-phosphate dehydrogenase(GAPDH)

Summary for 9UNY

Entry DOI	10.2210/pdb9uny/pdb
Descriptor	Glyceraldehyde-3-phosphate dehydrogenase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FORMAMIDE, ... (7 entities in total)
Functional Keywords	tetramer, active catalytic site cys152, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	147417.78
Authors	Fu, Q.,Xiao, Q.-Q. (deposition date: 2025-04-24, release date: 2026-07-29, Last modification date: 2026-08-12)
Primary citation	Xiao, Q.,Zhou, H.,Li, M.,Peng, Y.,Huang, Y.,Zhao, Y.,Chen, S.,Chen, H.,Zhang, C.,Yuan, Q.,Qiu, L.,He, Y.,Dai, Z.,Peng, T.,Fu, Q. GAPDH inhibition by oridonin integrates glycolytic inhibition and anti-inflammation to alleviate rheumatoid arthritis synovitis. Phytomedicine, 160:158650-158650, 2026 Cited by PubMed Abstract: Current therapeutic strategies for rheumatoid arthritis (RA) synovitis rely primarily on immunosuppression, with limited options targeting the diseased synovial fibroblasts (FLSs). Modulating the metabolic state of FLSs has been proposed as a potential approach to shift them toward an anti-inflammatory phenotype and alleviate synovitis. However, the molecular mechanisms that bridge FLS metabolism to anti-inflammatory defense remain largely unexplored. PubMed: 42542052 DOI: 10.1016/j.phymed.2026.158650 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation