9TFG

KIT kinase domain in complex with a 6-,7-dimethoxyquinoline-based compound (19)

This is a non-PDB format compatible entry.

Summary for 9TFG

• Entry DOI: 10.2210/pdb9tfg/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, 6,7-dimethoxy-4-[4-[5-(phenylmethyl)pyrimidin-2-yl]piperazin-1-yl]quinoline (3 entities in total)
• Functional Keywords: kit protein kinase, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, p10721, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 75271.91

Authors

Scrima, A.,Schulz, T.,Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2025-11-27, release date: 2026-07-15)

• Primary citation: Schulz, T.,Beerbaum, M.,Scrima, A.,Jantzen, H.,Teuber, A.,Muehlenberg, T.,Garcia-Fossa, F.,Weisner, J.,Mueller, M.P.,Sievers, S.,Bauer, S.,Rauh, D.; Structure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)