9T88

Cryo-EM structure of ESG-2-37-bound D3 dopamine receptor with mini-Go

This is a non-PDB format compatible entry.

Summary for 9T88

• Entry DOI: 10.2210/pdb9t88/pdb
• EMDB information: 55683
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, D(3) dopamine receptor,Lgbit, ... (6 entities in total)
• Functional Keywords: gpcr, agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 163437.93

Authors

Yardeni, E.H.,Kiss, D.J.,Keseru, G.M.,Shalev-Benami, M. (deposition date: 2025-11-12, release date: 2026-09-09)

• Primary citation: Hadas Yardeni, E.,Kiss, D.J.,Sanchez, J.,Shavit, K.,Szepesi Kovacs, D.,Egyed, A.,Vogt, C.D.,Gaitonde, S.A.,Glenn, J.,Canals, M.,Bouvier, M.,Newman, A.H.,Lane, J.R.,Keseru, G.M.,Shalev-Benami, M.; The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology; Sci Adv, 12:-, 2026; DOI: 10.1126/sciadv.aef7411

Experimental method

ELECTRON MICROSCOPY (2.74 Å)