9SI5

Crystal structure of DoxA in complex with reaction intermediate DHD

This is a non-PDB format compatible entry.

Summary for 9SI5

• Entry DOI: 10.2210/pdb9si5/pdb
• Descriptor: Cytochrome P-450 monooxygenase DoxA, PROTOPORPHYRIN IX CONTAINING FE, (7~{S},9~{S})-7-[(2~{R},4~{S},5~{S},6~{S})-4-azanyl-6-methyl-5-oxidanyl-oxan-2-yl]oxy-4-methoxy-6,9,11-tris(oxidanyl)-9-[(1~{R})-1-oxidanylethyl]-8,10-dihydro-7~{H}-tetracene-5,12-dione, ... (4 entities in total)
• Functional Keywords: p450, oxygenase, reaction intermediate sanpshot, tetracyclin biosynthesis, transferase
• Biological source: Streptomyces peucetius
• Total number of polymer chains: 2
• Total formula weight: 101688.20

Authors

Kim, R.Q.,Metsa-Ketela, M. (deposition date: 2025-08-28, release date: 2025-12-24)

• Primary citation: Koroleva, A.,Artukka, E.,Yamada, K.,Newmister, S.A.,Sherman, D.H.,Kim, R.Q.,Metsa-Ketela, M.; Metabolic Engineering of Doxorubicin Biosynthesis: Advancing P450 Catalysis through Redox Partner Optimization and Structural Analysis of DoxA; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.54 Å)