9S3J

Crystal structure of the human tumor necrosis factor receptor 1 extracellular domain in complex with a picolinic acid based ligand at 1.77A resolution

This is a non-PDB format compatible entry.

Summary for 9S3J

• Entry DOI: 10.2210/pdb9s3j/pdb
• Descriptor: Tumor necrosis factor receptor superfamily member 1A, membrane form, PHOSPHATE ION, 4-(4-fluorophenyl)pyridine-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: transmembrane signaling receptor, complex, small molecule, extracellular domain, cytokine-mediated activity, immune regulation, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 38198.89

Authors

Povlsen, K.,Bach, A.,Gajhede, M.,Narayanan, D. (deposition date: 2025-07-24, release date: 2026-07-01)

• Primary citation: Chedotal, H.,Povlsen, K.,Gajhede, M.,Narayanan, D.,Gotfredsen, C.,Bach, A.,Clausen, M.; Discovery of ligands for the TNFR1 extracellular domain using fragment-based drug discovery; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.77 Å)