9QZH

GID4 in complex with Compound 33

This is a non-PDB format compatible entry.

Summary for 9QZH

• Entry DOI: 10.2210/pdb9qzh/pdb
• Descriptor: Glucose-induced degradation protein 4 homolog, ~{N}-[3-fluoranyl-5-[4-[4-(methoxymethyl)piperidin-1-yl]carbonyl-5-methyl-furan-2-yl]phenyl]-4,4-dimethyl-piperidine-1-carboximidamide (2 entities in total)
• Functional Keywords: e3 ubiquitin ligase, ubiquitination, targeted protein degradation, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 79160.11

Authors

Pastok, M.W.,Gorecka-Minakowska, K.M.,Klejnot, M.,Skowron, A.N.,Wisniewski, J.,Walczak, M.J. (deposition date: 2025-04-23, release date: 2026-05-06)

• Primary citation: Pastok, M.W.,Gorecka-Minakowska, K.M.,Klejnot, M.,Skowron, A.N.,Wisniewski, J.,Walczak, M.J.; Novel chemical probes and conformational flexibility of GID4 - a substrate receptor of the Human CTLH E3 ligase complex; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.19 Å)