9Q8D

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH LIGAND

This is a non-PDB format compatible entry.

Summary for 9Q8D

• Entry DOI: 10.2210/pdb9q8d/pdb
• Descriptor: Monoglyceride lipase, (4~{a}~{R},8~{a}~{S})-6-[[6-[[2,4-bis(fluoranyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]carbonyl]-4,4~{a},5,7,8,8~{a}-hexahydropyrido[4,3-b][1,4]oxazin-3-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: alpha-beta hydrolase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35995.09

Authors

Grether, U.,Edelmann, M.,Gobbi, L.,Hilbert, M.,Huber, S.,Leibrock, L.,Benz, J. (deposition date: 2025-02-24, release date: 2026-03-11)

• Primary citation: Grether, U.,Edelmann, M.,Gobbi, L.,Schmalzbauer, S.,Beck, J.,Mueller, M.,Wittwer, M.,Haider, A.,Honer, M.,Collin, L.,Heer, D.,Topp, A.,Hilbert, M.,Huber, S.,Leibrock, L.,Benz, J.; Discovery of PET tracers using tritiated scaffolds at Roche on the specific example of optimizing a biomarker for brain-monoacylglycerol lipase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.54 Å)