9LN7

Alpha-7 nicotinic acetylcholine receptor bound to inhibitory bicyclic peptide KP2007 in a resting state.

Summary for 9LN7

• Entry DOI: 10.2210/pdb9ln7/pdb
• EMDB information: 63228
• Descriptor: Neuronal acetylcholine receptor subunit alpha-7, Inhibitory bicyclic peptide KP2007, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: nicotinic acetylcholine receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 298302.99

Authors

Chen, H.,Sun, D.,Tian, C. (deposition date: 2025-01-20, release date: 2026-01-21, Last modification date: 2026-08-05)

• Primary citation: Cao, X.,Chen, H.,Wang, X.,Yang, X.,Wang, T.,Zhou, L.,Shi, C.,Liu, S.,Tian, C.,Sun, D.; De novo discovery of unnatural and potent conotoxin-like bicyclic peptides through a phage-encoded library; Sci China Chem, 68:4276-4284, 2025; DOI: 10.1007/s11426-024-2543-1

Experimental method

ELECTRON MICROSCOPY (2.94 Å)