9I0C

E3 ubiquitin ligase CBL-B in complex with inhibitor

This is a non-PDB format compatible entry.

Summary for 9I0C

• Entry DOI: 10.2210/pdb9i0c/pdb
• Descriptor: E3 ubiquitin-protein ligase CBL-B, 1-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-5-(trifluoromethyl)pyridin-2-one, ZINC ION, ... (5 entities in total)
• Functional Keywords: ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 46351.71

Authors

Schimpl, M. (deposition date: 2025-01-14, release date: 2026-07-29)

• Primary citation: Chinn, A.J.,Quinn, T.R.,Boerth, J.A.,Kohara, K.,Bommakanti, G.; Inhibiting Ubiquitin ligases: A Case Study on the Discovery, Mechanism, and Optimization of Cbl-b Inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (2.123 Å)