9GCQ

Human Butyrylcholinesterase in complex with N1,N1-dimethyl-N2-(6-(naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3-yl)ethane-1,2-diamine

This is a non-PDB format compatible entry.

Summary for 9GCQ

• Entry DOI: 10.2210/pdb9gcq/pdb
• Descriptor: Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: butyrylcholinesterase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 62873.53

Authors

Brazzolotto, X.,Meden, A.,Knez, D.,Gobec, S.,Nachon, F. (deposition date: 2024-08-02, release date: 2025-08-13, Last modification date: 2026-08-26)

• Primary citation: Knez, D.,Malinak, D.,Meden, A.,Ferjančič Benetik, S.,Pišlar, A.,Kohoutova, Z.,Vondrackova, I.,Psotka, M.,Lycka, A.,Pulkrabkova, L.,Soukup, O.,Skarka, A.,Andrys, R.,Brazzolotto, X.,Igert, A.,Dias, J.,Nachon, F.,Detka, J.,Targosiński, F.,Hliabovich, D.,Brunzelle, J.S.,Shuvalova, L.,Salat, K.,Roy, S.M.,Watterson, D.M.,Musílek, K.,Gobec, S.; Dual Inhibitors; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c01461

Experimental method

X-RAY DIFFRACTION (2.62 Å)