9FVG

Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer AO184

This is a non-PDB format compatible entry.

Summary for 9FVG

• Entry DOI: 10.2210/pdb9fvg/pdb
• Descriptor: 14-3-3 protein sigma, Microtubule-associated protein tau, 1-(3-bromanyl-4-methyl-phenyl)-2-(4-ethylphenyl)imidazole, ... (4 entities in total)
• Functional Keywords: 14-3-3, tau, protein-protein interaction, covalent stabilization, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28404.74

Authors

van den Oetelaar, M.C.M.,Scheele, J.J.A.,Ottmann, C.,Brunsveld, L. (deposition date: 2024-06-27, release date: 2025-07-09)

• Primary citation: Oberheide, A.O.,van den Oetelaar, M.C.M.,Scheele, J.J.A.,Engelen, S.F.H.,Ottmann, C.,Cossar, P.,Brunsveld, L.; Site-selective stabilization of the 14-3-3/tau protein-protein interaction; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)