9EPZ

Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3337

This is a non-PDB format compatible entry.

Summary for 9EPZ

• Entry DOI: 10.2210/pdb9epz/pdb
• Descriptor: Casein kinase II subunit alpha, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: ck2, kinase, chemical, allosteric inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 83431.37

Authors

Kraemer, A.,Greco, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2024-03-20, release date: 2024-05-01, Last modification date: 2024-08-07)

• Primary citation: Greco, F.A.,Kramer, A.,Wahl, L.,Elson, L.,Ehret, T.A.L.,Gerninghaus, J.,Mockel, J.,Muller, S.,Hanke, T.,Knapp, S.; Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting.; Eur.J.Med.Chem., 276:116672-116672, 2024; PubMed: 39067440; DOI: 10.1016/j.ejmech.2024.116672

Experimental method

X-RAY DIFFRACTION (2.65 Å)