9B6F
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850
This is a non-PDB format compatible entry.
Summary for 9B6F
Entry DOI | 10.2210/pdb9b6f/pdb |
EMDB information | 44257 |
Descriptor | Transient receptor potential cation channel subfamily M member 8, CHOLESTEROL HEMISUCCINATE, (8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide (3 entities in total) |
Functional Keywords | trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, trpm8 activation, trpm8 inhibition, trpm8 desensitization, trpm8 antagonists, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 535650.26 |
Authors | Yin, Y.,Park, C.-G.,Zhang, F.,Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.-Y. (deposition date: 2024-03-25, release date: 2024-08-21) |
Primary citation | Yin, Y.,Park, C.G.,Zhang, F.,G Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.Y. Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10:eadp2211-eadp2211, 2024 Cited by PubMed: 39093967DOI: 10.1126/sciadv.adp2211 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.42 Å) |
Structure validation
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