Summary for 9AX6
Entry DOI | 10.2210/pdb9ax6/pdb |
Descriptor | GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, small gtpase, cancer, tricomplex, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 77751.78 |
Authors | Tomlinson, A.C.A.,Saldajeno-Concar, M.,Knox, J.E.,Yano, J.K. (deposition date: 2024-03-05, release date: 2024-04-17, Last modification date: 2024-06-12) |
Primary citation | Jiang, J.,Jiang, L.,Maldonato, B.J.,Wang, Y.,Holderfield, M.,Aronchik, I.,Winters, I.P.,Salman, Z.,Blaj, C.,Menard, M.,Brodbeck, J.,Chen, Z.,Wei, X.,Rosen, M.J.,Gindin, Y.,Lee, B.J.,Evans, J.W.,Chang, S.,Wang, Z.,Seamon, K.J.,Parsons, D.,Cregg, J.,Marquez, A.,Tomlinson, A.C.A.,Yano, J.K.,Knox, J.E.,Quintana, E.,Aguirre, A.J.,Arbour, K.C.,Reed, A.,Gustafson, W.C.,Gill, A.L.,Koltun, E.S.,Wildes, D.,Smith, J.A.M.,Wang, Z.,Singh, M. Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers. Cancer Discov, 14:994-1017, 2024 Cited by PubMed: 38593348DOI: 10.1158/2159-8290.CD-24-0027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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