8ZYQ

Cryo-EM Structure of pimozide-bound hERG Channel

Summary for 8ZYQ

Entry DOI	10.2210/pdb8zyq/pdb
EMDB information	60576
Descriptor	Potassium voltage-gated channel subfamily H member 2, 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one (2 entities in total)
Functional Keywords	drug toxicity, potassium ion, herg, cryo-em, membrane protein, transport protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	367629.89
Authors	Miyashita, Y.,Moriya, T.,Kato, T.,Kawasaki, M.,Yasuda, Y.,Adachi, N.,Suzuki, K.,Ogasawara, S.,Saito, T.,Senda, T.,Murata, T. (deposition date: 2024-06-18, release date: 2024-09-18, Last modification date: 2024-10-09)
Primary citation	Miyashita, Y.,Moriya, T.,Kato, T.,Kawasaki, M.,Yasuda, S.,Adachi, N.,Suzuki, K.,Ogasawara, S.,Saito, T.,Senda, T.,Murata, T. Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors. Structure, 2024 Cited by PubMed: 39321803 DOI: 10.1016/j.str.2024.08.021 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.18 Å)

Structure validation