8ZFP

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and MRL24

8ZFP の概要

• エントリーDOI: 10.2210/pdb8zfp/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-phenylbenzamide, (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID, ... (4 entities in total)
• 機能のキーワード: nuclear receptors, tzds, drug design, therapeutic targets, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64507.37

構造登録者

Shang, J.,Kojetin, D.J. (登録日: 2024-05-08, 公開日: 2024-08-07)

• 主引用文献: Shang, J.,Kojetin, D.J.; Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.; Elife, 2024; DOI: 10.7554/eLife.99782.1

実験手法

X-RAY DIFFRACTION (2.48 Å)