8ZCK

Serial Femtosecond Crystallography Structure of Fc Fragment of Human IgG1 from Biosimilar VEGF-Trap

8ZCK の概要

• エントリーDOI: 10.2210/pdb8zck/pdb
• 分子名称: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: fusion protein, immunoglobulin, n-glycans, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50155.00

構造登録者

Destan, E.,DeMirci, H. (登録日: 2024-04-30, 公開日: 2024-05-08, 最終更新日: 2025-05-21)

• 主引用文献: Destan, E.,Turkut, E.,Aldeniz, A.,Kang, J.,Tosha, T.,Yabashi, M.,Yilmaz, B.,Timucin, C.,Matsuura, H.,Kawano, Y.,Cinkaya, I.,Demirci, H.; Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF-Trap; Small Struct, 2025; DOI: 10.1002/sstr.202400680

実験手法

X-RAY DIFFRACTION (2 Å)